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Muscle fiber necroptosis in pathophysiology of idiopathic inflammatory myopathies and its potential as target of novel treatment strategy

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Considering the deleterious effects of Mn on BBB, studies have investigated the in vivo mechanisms underlying the Mn uptake by brain and their relationship with the BBB

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They identified the mutations that had a detrimental impact on binding, which allowed them to map the RBD sections indispensable for ACE2 attachment

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